Santos Sisters #1 bills itself as “Finally, a comic for Generation X” on its cover, and that exasperated pseudo-serious-but-completely-joking tone carries throughout its 56 pages. It’s a delightful-looking newsprint comic, almost completely done in Dan DeCarlo cartoon stylings by creators Greg and Fake Petre, but with a violent superhero sheen and a knowing nod to the reader who has seen all of this before, but maybe not in this exact way - and not usually with this much playfulness.
The implied conceit of this self-published (but now distributed by Floating World) comic is that it’s a superhero comedy from the Archie stable, with garishly colored three- to eight-page stories such as “Santos Sisters in ‘Scope: Feel the Tingle’” and “The Santos Sisters in ‘Outta Gas, Kiss My Dolphin Ass’”. The Santos Sisters themselves, Ambar and Alana, get an origin on the inside front cover in what looks like a travel or shampoo ad pastiche, a single image with text that reads: “One day while combing the beach, the Santos Sisters discovered a pair of beautiful medallions... What happened next changed their lives, forever.” What happened next, apparently, is that they put on medallions imbued with the powers of a goddess, “Madame Sosostris”, and can transform at will into flying, gun-wielding, mask-wearing murder-heroes with hearts of, if not gold, than at least candy. They are not altruistic, but they lean toward goodness. Not that any of these details matter all that much - the premise is not a setup for explorations of heroism, but rather as an engine for delivering weirdness and comedy. — The Comics Journal